Fragile X mental retardation protein: from autism to neurodegenerative disease
نویسنده
چکیده
INTRODUCTION Fragile X mental retardation protein (FMRP) is a RNA binding protein, the absence of which due to silencing of the FMR1 gene causes fragile X syndrome, an X-linked neurodevelopmental disorder (Bassell and Warren, 2008; Bhakar et al., 2012; Santoro et al., 2012). FMRP regulates the transport, stability and translation of its mRNA targets. Loss of FMRP alters translational control and receptor-mediated signaling pathways, leading to aberrant dendritic spine dynamics, synaptic
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عنوان ژورنال:
دوره 9 شماره
صفحات -
تاریخ انتشار 2015